Modified coordinate method to solve multicriteria optimization problems on combinatorial configurations.

We propose an approach to solve a multicriteria optimization problem on combinatorial configuration of permutations by using graph theory, taking into account the properties and structure of the set of permutations. The subprogram of the method of searching for configuration points that uses the coordinate method in the proposed modified approach is described

An approach to solving discrete vector optimization problems over a combinatorial set of permutations.

Complex discrete multicriteria problems over a combinatorial set of permutations are analyzed. Some properties of an admissible domain for a combinatorial multicriteria problem embedded into an arithmetic Euclidian space are considered. Optimality conditions are obtained for different types of effective solutions. A new approach to solving the problems formulated is constructed and substantiated

Radioactive contamination of ZnWO4 crystal scintillators

The radioactive contamination of ZnWO4 crystal scintillators has been measured deep underground at the Gran Sasso National Laboratory (LNGS) of the INFN in Italy with a total exposure 3197 kg x h. Monte Carlo simulation, time-amplitude and pulse-shape analyses of the data have been applied to estimate the radioactive contamination of the ZnWO4 samples. One of the ZnWO4 crystals has also been tested by ultra-low background gamma spectrometry. The radioactive contaminations of the ZnWO4 samples do not exceed 0.002 -- 0.8 mBq/kg (depending on the radionuclide), the total alpha activity is in the range: 0.2 - 2 mBq/kg. Particular radioactivity, beta active 65Zn and alpha active 180W, has been detected. The effect of the re-crystallization on the radiopurity of the ZnWO4 crystal has been studied. The radioactive contamination of samples of the ceramic details of the set-ups used in the crystals growth has been checked by low background gamma spectrometry. A project scheme on further improvement of the radiopurity level of the ZnWO4 crystal scintillators is briefly addressed.Comment: 15 pages, 8 figures, 6 tables, submitted for publicatio

Theoretical and methodological aspects of comparative studies in the field of health economics

The aim of the study – to do determination of theoretical and methodological approaches to using the methodology of comparative health economics in conditions of restrictionsЦель исследования - Определение теоретических и методологических подходов использования методологии 1084 компаративистики экономики здравоохранения в условиях ограничений

Clinical and Morphological Features of Dysplasia and Early Gastric Cancer in the Patients with Autoimmune Gastritis

Аim: to analyze a series of cases of dysplasia and early gastric cancer developed in patients with autoimmune gastritis (AIG), and to identify their clinical and morphological features.Materials and methods. The study included six cases of detection of early gastric cancer on the background of AIG. Four out of six patients underwent endoscopic treatment, and in three out of six cases patients underwent endoscopic mucosectomy with dissection in the submucosal layer. One patient underwent endoscopic surgery in 2017, he continues annual dynamic follow-up without signs of tumour recurrence. A female patient with type 1 neuroendocrine tumour and mild dysplasia is awaiting treatment.Results. In five out of six patients with AIG, the localization of lesions prevailed in the stomach body, while all detected tumours were early ones, and according to the immunophenotype — of a gastric type. The presented cases of tumours were not accompanied by hyperplasia of neuroendocrine cells directly in the area of the tumour itself, but only in the surrounding gastric mucosa. Additionally, several cases of early gastrointestinal stromal tumours were found, which were characterized by low proliferative activity and had small sizes.Conclusion. The predominance of pseudopyloric metaplasia in the surrounding mucosa allows us to consider pseudopyloric metaplasia as a potentially significant change in the gastric mucosa of patients with AIG that may precede the development of gastric cancer

A Tradeoff Drives the Evolution of Reduced Metal Resistance in Natural Populations of Yeast

Various types of genetic modification and selective forces have been implicated in the process of adaptation to novel or adverse environments. However, the underlying molecular mechanisms are not well understood in most natural populations. Here we report that a set of yeast strains collected from Evolution Canyon (EC), Israel, exhibit an extremely high tolerance to the heavy metal cadmium. We found that cadmium resistance is primarily caused by an enhanced function of a metal efflux pump, PCA1. Molecular analyses demonstrate that this enhancement can be largely attributed to mutations in the promoter sequence, while mutations in the coding region have a minor effect. Reconstruction experiments show that three single nucleotide substitutions in the PCA1 promoter quantitatively increase its activity and thus enhance the cells' cadmium resistance. Comparison among different yeast species shows that the critical nucleotides found in EC strains are conserved and functionally important for cadmium resistance in other species, suggesting that they represent an ancestral type. However, these nucleotides had diverged in most Saccharomyces cerevisiae populations, which gave cells growth advantages under conditions where cadmium is low or absent. Our results provide a rare example of a selective sweep in yeast populations driven by a tradeoff in metal resistance